{"id":86,"date":"2025-08-09T12:52:10","date_gmt":"2025-08-09T12:52:10","guid":{"rendered":"https:\/\/pnpmind.info\/home\/"},"modified":"2026-06-22T07:57:47","modified_gmt":"2026-06-22T07:57:47","slug":"home","status":"publish","type":"page","link":"https:\/\/pnpmind.info\/de\/","title":{"rendered":"Home"},"content":{"rendered":"
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Research Profile of the PNP-MIND Group<\/h2>\n\n\n\n

The research group PNP-MIND<\/strong>
(Perinatal Neonatal Pediatric Intensive Care \u2013 Machine Learning \u2013 Intensive Care \u2013 Neurodevelopment \u2013 Demographics<\/em>) focuses on translational research at the intersection of neonataler und p\u00e4diatrischer Intensivmedizin,<\/strong>, neurologischer Entwicklungsforschung<\/strong>und datengetriebener Modellierung.<\/strong>.<\/p>\n\n\n\n

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PNP-Mind goals<\/h2>\n\n\n\n

Our work centers on investigating the long-term neurological, cognitive, and somatic outcomes<\/strong> of children with a history of intensive care. We utilize retrospective and prospective cohorts<\/strong>, standardized clinical data sets<\/strong>, and structured follow-up assessments<\/strong>, which are analyzed using machine learning (ML)<\/strong> and artificial intelligence (AI)<\/strong> methods. <\/p>\n\n\n\n

The aim is to identify critical developmental phases<\/strong>, recognize risk factors early, and develop evidence-based predictive models<\/strong> that can be applied in clinical practice. Insights from these analyses are directly integrated into clinical guidelines and medical education curricula<\/strong>.<\/p>\n\n\n\n

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Research priorities<\/a><\/div>\n\n\n\n
Publications<\/a><\/div>\n<\/div>\n<\/div>\n\n\n\n
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Current research priorities include<\/h3>\n\n\n\n

NeoNEVS (NEOnatal NEuro-cerebral Volume ASessment)<\/em>:<\/strong> which investigates early postnatal brain volume growth via cranial ultrasound and its relevance for long-term neurocognitive outcomes in preterm infants<\/p>\n\n\n\n

NEOGAIN (Nortase Enzyme Optimization for Growth in At-risk Infants with Nutritional deficits)<\/em>:<\/strong> Analyses of the impact of enteral nutrition<\/strong> and pancreatic enzyme supplementation<\/strong> on postnatal growth in extremely preterm infants;<\/p>\n\n\n\n

VANOKI <\/strong>(Vaskul\u00e4rer Notfallzugang in der neonatalen Erstversorgung \u2013 Kan\u00fclierung der Nabelvene vs. Intraoss\u00e4re Kan\u00fcle)<\/strong><\/em>: A prospective bench study<\/strong> comparing the functionality and feasibility of intraosseous versus umbilical venous access in neonatal resuscitation scenarios;<\/p>\n\n\n\n

TelEmergencyBaby:<\/strong> The implementation and evaluation of telemedicine approaches<\/strong> to enhance acute and follow-up care in neonatal intensive care medicine.<\/p>\n\n\n\n

PROMISE (Preterm Rupture Outcomes: Maternal, Inflammatory, and Sonographic Evaluation)<\/em>:<\/strong> This study investigates how maternal, sonographic, and inflammatory factors predict neonatal respiratory outcomes and mortality following second-trimester preterm prelabor rupture of membranes (PPROM).<\/p>\n\n\n\n

NeoRISC (Neonatal RIsc StratifiCation<\/em>)<\/strong>: AI-driven clinical decision support project that uses longitudinal NICU data from extremely preterm infants to predict major neonatal morbidities, enabling earlier interventions and personalised care.<\/p>\n<\/div>\n<\/div>\n\n\n\n

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Publications<\/h2>\n\n\n\n
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06.2026<\/td>Maternal and Neonatal Determinants of Respiratory Outcome Following Second-Trimester PPROM: A Multi-Domain Machine Learning Analysis<\/strong><\/strong><\/strong><\/strong>
Diagnostics<\/em>
DOI: 10.3390\/diagnostics16121911\u00a0<\/em>
Loth, S.; …; Bieber, A,; Brickmann, C.; <\/td><\/tr>
06.2026<\/td>Neurodevelopmental Outcome in Very Low Birth Weight
Preterm Infants: An Exploratory Multivariable Analysis
Including Sonographic Brain Volume Trajectories\u2014Data from
the NeoNEVS Project<\/strong><\/strong><\/strong><\/strong>
Children<\/em>
DOI: 10.3390\/children13060815\u00a0<\/em>
Loth, S.; …; Bieber, A,; Brickmann, C.; <\/td><\/tr>
04.2026<\/td>Critical congenital heart defects outside a paediatric cardiology center \u2013 combined expertise and resources from a cohort study<\/strong><\/strong>
BMC Pediatrics<\/em>
DOI: 10.1186\/s12887-026-06887-3<\/em>
Brickmann, C.; \u2026 Dammert, A.<\/td><\/tr>
04.2026<\/td>Identification of risk factors of cystic periventricular leukomalacia in preterm infants<\/strong>
Frontiers in Pediatrics;<\/em>
DOI: 10.3389\/fped.2026.1758972
Lampe, R.; \u2026 Sidorenko, I.; \u2026 Brickmann, C.<\/td><\/tr>
04.2026<\/td>The Relationship Between Sonographically Assessed Volumetric Brain Development in VLBW Preterm Infants and Neurodevelopmental Outcome at 2 Years of Age \u2013 Data from the NeoNEVS Project<\/strong>
Frontiers in Pediatrics;<\/em>
DOI: 10.3389\/fped.2026.1769403
Brickmann C; \u2026 Kr\u00fcger M; \u2026 Loth, S.;<\/td><\/tr>
04.2026<\/td>PROMISE – Impact of Maternal and Neonatal Risk Factors on the Respiratory Outcome of Extremely Preterm Infants Following PPROM in the second trimester of pregnancy<\/strong>
Frontiers in Pediatrics;<\/em>
DOI:10.3389\/fped.2026.1776970
Brickmann C; \u2026 Loth, S.; \u2026 Kr\u00fcger M;<\/td><\/tr>
03.2026<\/td>Pediatric Intensive Core Outcomes \u2013 a modified Delphi consensus process (PIC-CO)<\/strong>.<\/strong>  
Critical Care; <\/em>
DOI: 10.1186\/s13054-026-05878-1<\/em>
Mand, N.; \u2026 Brickmann, C.*; Bruns, N.*<\/td><\/tr>
02.2026<\/td>NEOnatal NEuro-cerebral Volume ASessment (NeoNEVS): Sonographically Assessed Volumetric Brain Development in Very Low Birth Weight Preterm Infants and its Clinical Determinants.<\/strong>  
Children<\/em>
DOI: 10.3390\/children13020281<\/em><\/em><\/em>
Brickmann, Christian; Lampe, Ren\u00e9e, \u2026 Sidorenko, Irina; \u2026 Loth, Simon<\/td><\/tr>
08.2025<\/td>Development of a standardized handover for critically ill premature and newborn infants for interhospital transport in Bavaria<\/strong><\/strong>
Zeitschrift f\u00fcr Geburtshilfe und Neonatologie<\/em>; <\/em>
DOI: 10.1055\/a-2659-7541<\/em><\/em>
Wolff, J.; \u2026 Brickmann, C.; \u2026 Wellmann, S.<\/td><\/tr>
07.2025<\/td>Numerical estimation of optimal limits of cerebral blood flow and oxygen partial pressure in brain tissue of preterm infants<\/strong>
Computer Methods and Programs in Biomedicine; <\/em>
DOI: 10.1016\/j.cmpb.2025.108984<\/em>
Sidorenko, I.; \u2026 Brickmann, C.; \u2026 Lampe, R.;<\/td><\/tr>
05.2025<\/td>Teaching Neonatal Emergency Umbilical Venous Access to Untrained Medical Staff: A Pilot Study Using Video Instruction and Real Umbilical Cords <\/strong>
Advances in Medical Education and Practice;
DOI: 10.2147\/AMEP.S516071<\/em>
Brickmann C; \u2026 Hentschel, R; <\/td><\/tr>
01.2025<\/td>Learning and working on an interprofessional training ward in neonatology improves interprofessional competencies <\/strong>
Frontiers in Medicine
DOI: 10.3389\/fmed.2025.1483551<\/em>
Schwarz, H.; Straub, C.; \u2026 Brickmann C; \u2026 Kr\u00fcger M; <\/td><\/tr>
06.2024<\/td>Neonatal therapy after maternal central neurotropic drug exposure \u2013 a retrospective cohort study<\/strong>
Journal of Maternal-Fetal & Neonatal Medicine<\/em>
DOI: 10.1080\/14767058.2024.2356038<\/em>
Wecker S; Dammert AS; Scholz C; Kr\u00fcger M; Hauer J; Brickmann C; <\/td><\/tr>
12.2020<\/td>Emergency button cannula vs. umbilical catheter as neonatal emergency umbilical vein access \u2013 a randomized cross-over pilot study<\/strong>
Journal of Perinatal Medicine<\/em>
DOI: 10.1515\/jpm-2022-0071<\/em>
Brickmann, C.; Zang, F.; Klotz, D.; Kunze, M.; Lenz, S.; Hentschel, R<\/td><\/tr><\/tbody><\/table><\/figure>\n<\/div>\n<\/div>\n\n\n\n
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The Research Group<\/h3>\n\n\n\n

Responsible members are neonatologist and pediatric intensive care physician Dr. Christian Brickmann and psychologist M.Sc. Simon Loth. Our research group collaborates closely with the Research Unit of the Buhl-Strohmaier Foundation for Pediatric Neuroorthopedics and Cerebral Palsy<\/strong> (Markus W\u00fcrth Endowed Professorship, Prof. Dr. Ren\u00e9e Lampe) and the TEMPiS Center at M\u00fcnchen Klinik<\/strong>, enabling a wide-ranging, interdisciplinary research approach from acute care to long-term outcomes.<\/p>\n\n\n\n

We are committed to advancing data-based, predictive, and individualized care<\/strong> for vulnerable pediatric patient populations through tight integration of clinical practice, healthcare structures, and academic research<\/strong>.<\/p>\n\n\n\n

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Christian Brickmann<\/h3>\n\n\n\n

Dr. Christian Brickmann<\/strong> studied medicine at Philipps University of Marburg and has worked at university hospitals in Marburg and Freiburg throughout his career. He is a pediatrician, neonatologist, and specialist in pediatric intensive care medicine. Currently, he combines his clinical work as an attending physician at M\u00fcnchen Klinik<\/em> with research at the Technical University of Munich (TUM). His research addresses epidemiological and practical aspects of neonatology, with a recent emphasis on integrating digital tools into clinical practice. He regularly presents his findings at national and international conferences and is an appointed member of the Ethics Committee of the Technical University of Munich.<\/p>\n<\/div>\n<\/div>\n\n\n\n

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Simon Loth<\/h3>\n\n\n\n

Simon Loth<\/strong> holds a Bachelor\u2019s and Master\u2019s degree in Psychology from PFH G\u00f6ttingen (2024, 2025) and is currently studying Medicine. He is a shareholder in a company providing advanced out-of-hospital emergency medicine training for professional medical personnel. His research focuses on the application of digital technologies to questions in neurodevelopment, aiming to connect cognitive science with practical healthcare solutions. He has presented his work at national and international conferences.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n

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Alexander Bieber<\/h3>\n\n\n\n

Alexander Bieber<\/strong> studied Microsystems Engineering, graduating with a German Diplom degree. In the early 2000s, he transitioned into entrepreneurship, founding a software services company where he served as CEO until the mid-2010s. Since 2013, he has brought this combined technical and leadership expertise to enterprise environments, working as a technical project manager and software solution architect. His current focus centers on designing scalable software architectures, integrating complex system solutions including machine learning programming and leading technical projects from conception to deployment.<\/p>\n<\/div>\n<\/div>\n\n\n\n

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Moritz Ortmann<\/h3>\n\n\n\n

Moritz Ortmann<\/strong> studied medicine at LMU Munich and currently works as resident physician in the Department of Neonatology and Pediatric Intensive Care Medicine at M\u00fcnchen Klinik. He has many years of experience in preclinical emergency care, international repatriation services, and is an AHA instructor in PALS and ACLS courses. His research focuses on improving initial care for premature and newborn babies, particularly with regard to intravascular access routes.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"

Research Profile of the PNP-MIND Group The research group PNP-MIND(Perinatal Neonatal Pediatric Intensive Care \u2013 Machine Learning \u2013 Intensive Care \u2013 Neurodevelopment \u2013 Demographics) focuses on translational research at the intersection of neonatal and pediatric intensive care, neurodevelopmental science, and data-driven modeling. PNP-Mind goals Our work centers on investigating the long-term neurological, cognitive, and somatic […]<\/p>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"no-title","meta":{"footnotes":""},"class_list":["post-86","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/pnpmind.info\/de\/wp-json\/wp\/v2\/pages\/86","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pnpmind.info\/de\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pnpmind.info\/de\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pnpmind.info\/de\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pnpmind.info\/de\/wp-json\/wp\/v2\/comments?post=86"}],"version-history":[{"count":0,"href":"https:\/\/pnpmind.info\/de\/wp-json\/wp\/v2\/pages\/86\/revisions"}],"wp:attachment":[{"href":"https:\/\/pnpmind.info\/de\/wp-json\/wp\/v2\/media?parent=86"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}